The main objective of the 8th AMIT Congress is to present to an audience of professionals some of the most important developments in the field of infectious diseases, with particular attention to the management of diseases caused by multi-drug resistant (MDR) bacteria and by new viruses such as SARS-CoV-2, which caused the current pandemic.The problem of diseases caused by MDR bacteria remains current, and all international organizations (WHO, OCSE, CDC, ECDC, ISS) continue, even in a contingent pandemic situation, to focus attention on the epidemiological, therapeutic, and preventive management of infections caused by such MDR microorganisms. These aspects will be dealt with in several sessions at the 8th AMIT Congress, with contributions by top experts in each field (see program). Currently, all heath organizations implement “One Health” management models, in which maintaining an ecological balance of human, animal, and environmental health is deemed essential. Each of these plays a precise role in the determinism of MDR diseases. Global resistance rates in humans vary significantly from country to country and depend on numerous factors. In Europe, the use of antibiotics varies at both the community and hospital level. Antibiotic stewardship protocols are not always applied at the scale level, but vary from country to country, and rates differ for almost all highly-resistant microorganisms. This highly diversified context poses the problem of standardizing models for the surveillance, control, and application of therapeutic guidelines throughout Europe, while constantly considering local epidemiology as the driver for local management decisions.The sessions of the 8th AMIT Congress will focus on many critical aspects, such as antibiotic-resistance, hospital-acquired infections and the various strategies to be applied: functional coordination and integration among institutional levels and various territorial responsibilities, surveillance of invasive infections caused by Carbapenemase-producing Enterobacteriaceae (CPE), greater awareness regarding the use of antibiotics, and the definition of a surveillance and control program for hospital-acquired infections.The 8th AMIT Congress will also present important sessions on issues related to viral infections, with specific reference to the SARS-CoV-2 pandemic. The sessions will cover all epidemiological, virological, and clinical aspects of SARS-CoV-2, as well as possible current and future therapies. The Congress will also discuss future vaccinations for the prevention of various contagious diseases caused by viruses or by bacteria.To conclude, the 8th AMIT Congress will cover topics related to the HIV pandemic, with specific reference to new therapeutic options and to new strategic approaches to maintain virological suppression and to safeguard patients’ quality of life.